Medulloblastoma and central nervous system germ cell tumors in adults: is pediatric experience applicable?

摘要: Medulloblastoma and central nervous system (CNS) germ cell tumors are very rare in adults, while they account for 25% 5% of brain children, respectively (Pastore et al. Eur J Cancer 42:2064-208, 2006). Pediatric experiences, mostly from randomized controlled clinical trials, have led to different tailored treatments, based on various risk factors, including histology, extent disease. For medulloblastoma, biological features recently emerged that enable therapies be scaled down some cases, or pursued more aggressively the event chromosomal and/or genetic alterations (Massimino Crit Rev Oncol Hematol 105:35-51, 2016). Such refinements still impossible adult patients due lack similar trials might provide same a understanding regarding patients' prognosis, long-term survival, quality life, acute late toxicities. This review aims contribute debate treatment adults with these two diseases promote creation broad-based, national international advance our knowledge this area share skills between pediatric oncologists as adolescent young (AYA) tumor boards currently requiring.