Understanding the Correlation between Tomographic and Biomechanical Severity of Keratoconic Corneas

摘要: Purpose. To evaluate correlation between tomographic gradation of keratoconus (KC) and its corresponding air-puff induced biomechanical response. Methods. Corneal tomography biomechanics were measured with Scheimpflug imaging in 44 normal 92 KC corneas. Deformation waveform was also analyzed Fourier series. A custom severity scale used from 1 to 3 as the most severe grade. Tomographic variables assessed among grades. Sensitivity specificity using receiver operating characteristics (ROC). Results. Curvature significantly different disease (P 0.05). All had an area under ROC curve greater than 0.5. The root mean square cosine coefficients best (0.92, cut-off: 0.027, sensitivity: 83%, specificity: 88.6%). Spearman coefficient significant < However, segregation did not result concomitant Conclusions. There lack difference mild grades, despite progressive corneal thinning. Mathematical models that estimate modulus deformation may be more useful.