Effect of splenectomy on tolerance to combination chemotherapy in patients with lymphoma.

摘要: Enhanced tolerance to combination chemotherapy has been cited as an ancillary benefit of staging laparotomy and splenectomy in Hodgkin’s disease. Seventeen patients with disease 15 non-Hodgkin’s lymphoma were subjected nontherapeutic part the procedure prior their initialtreatment MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) or (cyclophosphamide, chemotherapy, respectively. Matched control comparable age, pathologically proven stage, presence absence bone marrow previous radiotherapy selected. Although leukocyte (in patients) platelet counts both groups) significantly higher during most first six cycles therapy, there was no difference number which a count below 1000 (or 2000 disease) 50,000 recorded splenectomized patients. The total dose all drugs actually delivered, time required complete treatment, portion entering remission not different two groups. We have found evidence that per se without findings hypersplenism, improves ability administer planned amounts initial chemotherapy. I NDICATIONS FOR SPLENECTOMY malignant varied, but generally included painful bulky splenomegaly unequivocal hypersplenism,”2 associated autoimmune hemolytic anemia thrombocytopenia.3 Significant mortality can be operation long-standing disseminated lymphoma.4 As result, early appearance hypersplenism recently suggested maneuver might allow more vigorous treatment subsequent course disease.5 chemotherapeuticagents lymphomas noted by several groups after for anemia, leukopenia, thrombocytopenia.�8 This observation could lead advocacy hope producing easier delivery myelosuppressive antineoplastic therapy. An opportunity assess this potential arises those whom performed pretreatment process. Reduction hematologic toxicity extended field lymph node irradiation indeed reported,9” although none these studies