Case/control study of the role of splenectomy in chronic lymphocytic leukemia.
作者： J F Seymour , J D Cusack , S A Lerner , R E Pollock , M J Keating
关键词: Leukemia 、 Chronic lymphocytic leukemia 、 Atelectasis 、 Retrospective cohort study 、 Internal medicine 、 Perioperative 、 Splenectomy 、 Surgery 、 Hematologic Response 、 Medicine 、 Performance status
摘要: PURPOSEThis retrospective analysis was performed to evaluate critically the morbidity and mortality of splenectomy in patients with chronic lymphocytic leukemia determine probability hematologic response. Further, using a case/control format based on multivariate analysis-derived predictors survival, we evaluated influence survival.PATIENTS AND METHODSBetween 1971 1993, 55 underwent splenectomy. They were compared fludarabine-treated who had been matched for age, serum albumin level, sex, hemoglobin Rai stage, number prior therapies, time from diagnosis.RESULTSIn perioperative period, blood-product usage modest, common morbidities limited minor infections 18% pneumonia/atelectasis 25%. Perioperative 9%. Deaths related septic complications all cases associated preoperative performance status > or = 2 (P .05)....
utsystem.edu参考文章(26)
H. Kantarjian, C. Koller, S. O'Brien, W. Plunkett, L. E. Robertson, M. Andreeff, M. Beran, S. Lerner, M. J. Keating, A 3-day schedule of fludarabine in previously treated chronic lymphocytic leukemia. Leukemia. ,vol. 9, pp. 1444- 1449 ,(1995)
Balcerzak Sp, Kopecky Kj, Hutton Jj, Grever Mr, Greenberg Br, Talley R, Von Hoff Dd, Coltman Ca, Files Jc, Fludarabine monophosphate: a potentially useful agent in chronic lymphocytic leukemia. Nouvelle revue française d'hématologie. ,vol. 30, pp. 457- 459 ,(1988)
JF Seymour, R Kurzrock, EJ Freireich, EH Estey, 2-chlorodeoxyadenosine induces durable remissions and prolonged suppression of CD4+ lymphocyte counts in patients with hairy cell leukemia Blood. ,vol. 83, pp. 2906- 2911 ,(1994) , 10.1182/BLOOD.V83.10.2906.2906
KR Rai, A Sawitsky, EP Cronkite, AD Chanana, RN Levy, BS Pasternack, Clinical staging of chronic lymphocytic leukemia. Blood. ,vol. 46, pp. 219- 234 ,(1975) , 10.1182/BLOOD.V46.2.219.219
DC Ihde, VT DeVita, GP Canellos, RC Young, Effect of splenectomy on tolerance to combination chemotherapy in patients with lymphoma. Blood. ,vol. 47, pp. 211- 222 ,(1976) , 10.1182/BLOOD.V47.2.211.211
S O'Brien, H Kantarjian, M Beran, T Smith, C Koller, E Estey, LE Robertson, S Lerner, M Keating, Results of Fludarabine and Prednisone Therapy in 264 Patients With Chronic Lymphocytic Leukemia With Multivariate Analysis-Derived Prognostic Model for Response to Treatment Blood. ,vol. 82, pp. 1695- 1700 ,(1993) , 10.1182/BLOOD.V82.6.1695.1695
MJ Keating, S O'Brien, H Kantarjian, W Plunkett, E Estey, C Koller, M Beran, EJ Freireich, Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent. Blood. ,vol. 81, pp. 2878- 2884 ,(1993) , 10.1182/BLOOD.V81.11.2878.BLOODJOURNAL81112878
Frank Wilcoxon, Individual Comparisons by Ranking Methods Springer Series in Statistics. ,vol. 1, pp. 196- 202 ,(1992) , 10.1007/978-1-4612-4380-9_16
Bernt Ly, Dagfinn Albrechtsen, Therapeutic splenectomy in hematologic disorders. Effects and complications in 221 adult patients. Acta Medica Scandinavica. ,vol. 209, pp. 21- 29 ,(2009) , 10.1111/J.0954-6820.1981.TB11546.X
W Reinisch, M Willheim, M Hilgarth, C Gasché, R Mader, S Szepfalusi, G Steger, R Berger, K Lechner, G Boltz-Nitulescu, Soluble CD23 reliably reflects disease activity in B-cell chronic lymphocytic leukemia. Journal of Clinical Oncology. ,vol. 12, pp. 2146- 2152 ,(1994) , 10.1200/JCO.1994.12.10.2146