Diagnostik und Therapie der chronisch-lymphatischen Leukämie
作者： M. Rummel
DOI: 10.1007/S00761-002-0336-6
关键词:
摘要: Die chronisch-lymphatische Leukamie (CLL) ist die haufigste in den westlichen Landern und eine Erkrankung des hoheren Lebensalters. Sie charakterisiert durch Akkumulation von monoklonalen immuninkompetenten Lymphozyten im Knochenmark peripheren Blut. In 95% der Falle sind CLL-Lymphozyten B-Zellen mit einer niedrigen Proliferationsrate. Verdrangung normalen Hamatopoese fuhrt Verlauf zu Knochenmarkinsuffizienz zunehmender Anamie, Thrombozytopenie auch Neutropenie. Ein ausgepragtes Antikorpermangelsyndrom stellt, neben Neutropenie, hauptsachlichen Grund fur erhohte Infektanfalligkeit CLL-Patienten dar. Eine anhaltende Lymphozytose sowie Immunphanotypisierung dieser Zellen zur Diagnose CLL. Stadieneinteilung erfolgt nach Klassifikationen Rai Binet.
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