Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL)
作者： Melinda Kovács , Gábor Tornyos , Zsolt Matics , Miklós Mézes , Krisztián Balogh
DOI: 10.1016/J.ANIREPROSCI.2013.01.006
关键词: No-observed-adverse-effect level 、 Internal medicine 、 Hyperplasia 、 Urea 、 Adverse effect 、 Glutathione peroxidase 、 Chemistry 、 Testosterone 、 Toxin 、 Hormone 、 Endocrinology
摘要: Abstract T-2 toxin (T-2) was administered to adult Pannon White ( n =10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2mg/animal/day), and secondly mixed into the feed (0.33 0.66mg/kg feed). In experiment 0.1mg exposure resulted temporary decrease intake, slower increase gonadotropin-releasing hormone (GnRH) induced testosterone synthesis, slight centrolobular infiltration liver hyperplasia of Leydig cells. addition refusal effect, 0.2mg caused plasma albumin urea concentrations, lesser glutathione peroxidase (GPx) activity seminal plasma, greater (by 320%) ratio spermatozoa with cytoplasmic droplets, GnRH-induced liver, slightly hyperaemic testes increased proliferative The two smaller doses applied 0.66mg/kg) did not cause any significant adverse no observed. According these results No Observed Adverse Effect Level (NOAEL) rabbit males found be
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