Clinical Insights Into the Biology and Treatment of Pancreatic Cancer

摘要: Pancreatic cancer is a devastating disease with universally poor prognosis. In 2015, it estimated that there will be 48,960 new cases of pancreatic and 40,560 people die the disease. The 5-year survival rate 7.2% for all patients cancer; however, depends greatly on stage at diagnosis. Unfortunately, 53% already have metastatic diagnosis, which corresponds to 2.4%. Even 9% localized confined pancreas, still modest only 27.1%. These grim statistics highlight need ways identify cohorts individuals highest risk, methods screen those risk preinvasive pathologic precursors, development effective systemic therapies. Recent clinical translational progress has emphasized relationship diabetes, role stroma, interplay each these inflammation in pathobiology cancer. this article, we discuss relationships how they might translate into novel management strategies treatment