Multicentre analysis of long‐term outcome after surgical resection for gastric cancer liver metastases

摘要: Background The efficacy of surgical resection for gastric cancer liver metastases (GCLMs) is currently debated. Hitherto, no large-scale clinical studies have been conducted. Methods This retrospective multicentre study analysed a database consecutive patients with either synchronous or metachronous who underwent R0 GCLM between 1990 and 2010. Clinical data were collected from five centres in Japan. Survival curves assessed, parameters evaluated to identify predictors prognosis. Results A total 256 enrolled. The mean(s.d.) number hepatic tumours resected was 2·0(2·4). mortality rate 1·6 per cent. Median follow-up 65 (range 1–261) months. Recurrences detected 192 (75·0 cent). median interval recurrence 7 1–72) months, the dominant site (72·4 Actuarial 1-, 3- 5-year overall recurrence-free survival rates 77·3, 41·9 31·1 cent, 43·6, 32·4 30·1 respectively. times 9·4 months Multivariable analysis identified serosal invasion primary (hazard ratio (HR) 1·50; P = 0·012), three more (HR 2·33; P < 0·001) tumour diameter at least 5 cm 1·62; P = 0·005) as independent poor survival. Conclusion Clinically resectable rare, but strict careful patient selection can lead long-term following resection.