Clonality behind the increase of multidrug-resistance among non-invasive pneumococci in Southern Finland.

摘要: Multidrug-resistance among Streptococcus pneumoniae isolates, especially of serotype 19A, has increased in several countries recently. Even before the introduction pneumococcal conjugate vaccine into Finnish National Vaccination Programme, proportion multidrug-resistant (MDR) pneumococci had doubled from 2007 to 2008, when it reached 3.6% Southern Finland. Our aim was look for a possible association between antimicrobial susceptibility and clonality MDR isolates. Twelve non-invasive isolates non-susceptible penicillin, erythromycin, clindamycin, trimethoprim/sulfamethoxazole, doxycycline 2008 were available serotyping, genotyping by multilocus sequence typing (MLST), detection genes encoding macrolide resistance adherence-promoting pili. Two also resistant ceftriaxone. Five serotypes, 19F, 6B, 23F, 14, six genotypes three genetic lineages found, which CC320 largest. All this study carried erm(B) gene, additionally mef(A/E) gene. Eleven pilus islet 1, while 2 genes. The findings emphasize importance careful monitoring distribution pneumococci, now that antimicrobials vaccines are widespread use.