Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma.

摘要: Summary Background : The tumor suppressor homologue p63 is expressed in basal and parabasal layers of intraoral mucosa. Full length transcripts with transactivational domain (TA forms) present homology to p53 implicate functions governing cell proliferation, differentiation apoptosis control. To date studies show an increase expression oral dysplasia additionally high levels correlated poor prognosis for patients OSCC, whereas a possible link radiation resistance tumors has not been investigated yet. In the study we tested hypothesis being marker radioresistance overall survival OSCC. Methods Expression was labeled by immunohistochemistry pre-treatment biopsies collected from 33 Quantification labeling index (Li) based on relation positive cells count. Histological examination resection specimen allowed categorization response. Statistical analyses association between Li response were performed. Survival analysis utilized Kaplan–Meier estimates Cox regression model built (Li), T stage, N-stage chemotherapy presented as hazard ratios. Results All had enhanced expression. median 63.1% (range 36–87%). Tumors count >63.1% showed increased ( p  = 0.027). Overall higher  = 0.001) low value) multivariate confirmed significance prognostic survival. Conclusions results this advocate tissue be associated shorter promising biomarker should now larger patient counts.