In whole blood, LPS, TNF-alpha and GM-CSF increase monocyte uptake of 99mtechnetium stannous colloid but do not affect neutrophil uptake
作者： Stuart C. Ramsay , Jacqueline Maggs , Kellie Powell , Jodie Barnes , Natkunam Ketheesan
DOI: 10.1016/J.NUCMEDBIO.2006.04.002
关键词: Pharmacology 、 Immunology 、 Whole blood 、 Integrin alpha M 、 Phagocytic Cell 、 Lipopolysaccharide 、 Sepsis 、 Monocyte 、 Tumor necrosis factor alpha 、 Biology 、 Phagocytosis
摘要: 99mTechnetium stannous colloid (TcSnC) is used in white cell scanning. It labels neutrophils and monocytes via phagocytosis, with uptake mediated by the phagocytic receptor CD11b/CD18 neutrophils. Uptake of TcSnC altered gram-negative infection, possibly due to endotoxin component lipopolysaccharide (LPS) or cytokines released during infection (e.g., TNF-alpha IFN-gamma). Endotoxemia increased levels also occur inflammatory bowel disease. Another potential confounder labeling that sepsis patients may be treated GM-CSF G-CSF, which alter function. This study aimed determine how these factors affect cellular uptake.
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