The role of tumour necrosis factor in the kinetics of lipopolysaccharide-mediated neutrophil priming in whole blood.
作者： H. J. van Leeuwen , M. Van Der Tol , J. A. G. Van Strijp , J. Verhoef , K. P. M. van Kessel
DOI: 10.1111/J.1365-2249.2005.02748.X
关键词: Respiratory burst 、 Cytokine 、 Granulocyte 、 Immunology 、 Lipopolysaccharide 、 Priming (immunology) 、 Tumor necrosis factor alpha 、 Blood proteins 、 Whole blood 、 Chemistry
摘要: Summary Neutrophils can be primed by bacterial lipopolysaccharide (LPS) for an enhanced oxidative burst, which is a key element in the pathogenesis of Gram- negative sepsis. Some serum proteins (e.g. lipopolysaccharide-binding pro- tein) avidly bind LPS and markedly enhance receptor binding cellular activation while other factors (lipoproteins, bactericidal/permeability- increasing protein) neutralize prevent neutrophil activation. In this paper we examined kinetics priming reaction whole blood. To study balance between neutralization sen- sitive chemiluminescence assay was used blood system. able to prime neutrophils burst with optimum incubation time 25 min. However, neutralized very rap- idly t 1/2 10 After 20 min second factor already generated, shown monocyte-derived tumour necrosis (TNF).
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