Distinct effects of NPY13–36, a specific NPY Y2 agonist, in a model of rodent endotoxemia on leukocyte subsets and cytokine levels
作者： Jan Stadler , Tina Phan Le , Philipp Haas , Heike Nave
DOI: 10.1016/J.AANAT.2011.10.009
关键词:
摘要: Even now, sepsis remains a major problem in modern clinical medicine, leading to systemic inflammatory response including altered leukocyte subset distribution and increased cytokine release. As immune cells are known express NPY receptors, we investigated the effects of specific Y(2) receptor agonist (NPY(13-36)) and/or corresponding antagonist BIIE0246 treatment on blood (by FACS analyses) tissue immunohistochemistry) subsets as well levels IL-4, IL-6, IL-10, TNF-α, INF-γ Cytometric Bead Array) healthy acutely endotoxemic rats. Results show significant decrease monocytes after LPS challenge control animals 93%), NPY(13-36) treated 83%) 88%) compared controls. Endotoxemic showed increase TNF-α 98%) group. A with significantly stabilized level animals. This study indicates distinct subset- cytokine-specific vivo induced by an short-term challenge.
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