Selective effects of dopamine depletion and L-DOPA therapy on learning-related firing dynamics of striatal neurons.

摘要: Despite evidence that dopamine neurotransmission in the striatum is critical for learning as well movement control, little yet known about how learning-related dynamics of striatal activity are affected by depletion, a condition faced Parkinson's disease. We made localized intrastriatal 6-hydroxydopamine lesions rats and recorded within dopamine-depleted sensorimotor zone its contralateral correspondent animals learned conditional maze task. Rather than producing global, nonspecific elevations firing rate across task, depletion altered projection neuron fast-spiking interneuron selectively, with sharply task-specific cell type-specific effects, often, learning-stage selective effects well. Striatal neurons strong responses during runs had especially elevated responsiveness runs. Projection that, instead, fired most strongly before running showed pre-start rates, but not running, progressed. The severely patterning ensembles, after extended training. Remarkably, L-DOPA treatment almost entirely reversed depletion-induced pre-run neurons, their around start end By contrast, failed to normalize activity. Thus restoration on highly dependent only type, previously shown, also behavioral called state achieved.