Dopamine Is Required for the Neural Representation and Control of Movement Vigor

摘要: Progressive depletion of midbrain dopamine neurons (PDD) is associated with deficits in the initiation, speed, and fluidity voluntary movement. Models basal ganglia function focus on initiation deficits; however, it unclear how they account for speed or amplitude movement (vigor). Using an effort-based operant conditioning task head-fixed mice, we discovered distinct functional classes dorsal striatum that represent vigor. Mice PDD exhibited a progressive reduction vigor, along selective impairment its neural representation striatum. Restoration dopaminergic tone synthetic precursor ameliorated vigor representation, while suppression striatal activity during was sufficient to reduce Thus, input indispensable emergence mediates adaptive changes These results suggest refined intervention strategies Parkinson's disease.