Cardiac remodelling in rainbow trout Oncorhynchus mykiss Walbaum in response to phenylhydrazine-induced anaemia

摘要: We examined the nature, extent and timing of cardiac ventricular remodelling in response to chronic, chemically induced anaemia warm- cold-acclimated rainbow trout Oncorhynchus mykiss. Chronic was by bi-weekly injections phenylhydrazine hydrochloride (PHZ) resulted transient but large decreases haematocrit (Hct) haemoglobin concentration. After 2 weeks anaemia, relative mass (rM(V)) warm-acclimated had already increased significantly and, eighth week rM(V) 58% greater than sham-injected control fish. Temperature modulated anaemia-induced erythropoietic responses, as indicated cold-acclimation reducing slowing recovery. For example, fish, PHZ reduced Hct 8.8+/-1.9% (ranging from 4-16%) 15% over a 4-week period, whereas same treatment fish only 17.4+/-2.1% 6-29%) yet 28%. Cold-acclimated also recovered more slowly anaemia. In addition, maintained compact myocardium between 32% 37% during while responded with an increase (from 29% 37%). Routine output (Q) continuously monitored following single injection examine initial Contrary expectations, acute did not produce immediate, proportionate routine Q. fact, Q until decreased 10%, suggesting that may initially rely on venous oxygen stores compensate for arterial oxygen-carrying capacity. Thus, we conclude myocardial oxygenation, acclimation temperature work load could all influence trout.