Effect of ethanol on fatty acid metabolism in cultured hepatocytes: Dependency on incubation time and fatty acid concentration
作者： N. Grunnet , F. Jensen , J. Kondrup , J. Dich
DOI: 10.1016/0741-8329(85)90035-7
关键词: Fatty acid metabolism 、 Fatty acid synthesis 、 Ethanol metabolism 、 Cytosol 、 Diacylglycerol kinase 、 Fatty liver 、 Chemistry 、 Fatty acid 、 Biochemistry 、 Ethanol 、 Toxicology 、 Behavioral neuroscience 、 Health(social science) 、 Neurology 、 General Medicine
摘要: In a previous report it was shown that ethanol increases the rate of accumulation triacylglycerol by 90% in hepatocytes primary culture. This represents first known suitable model for vitro studies ethanol-induced fatty liver. The biochemical alterations causing this remain to be elucidated, however. present is (1) effect exhibits time lag 6-9 hours (2) increment content caused increased concentrations acids (3) acid uptake not affected (4) synthesis inhibited 20% (5) contents diacylglycerol and phospholipids are (6) addition cytosolic mitochondrial redox levels. It concluded likely exert its on redistributing between oxidation and/or storage secretion triacylglycerol.
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