Neuroactive steroids attenuate cocaine-induced sucrose intake in rats, but not cocaine-induced hyperactivity in mice.

摘要: Rationale: Neuroactive steroids, including the potent anticonvulsants ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one) and Co 2-1068 (3β-(4acetylphenyl)ethynyl-3α,21-dihydroxy-5β-20-one-21-hemisuccinate), have recently been shown to protect against cocaine-induced seizures. Objectives: The purpose of present experiments was determine whether attenuate acute behavioral effects cocaine unrelated Methods: In first experiment, locomotor (10–100 mg/ kg), pentobarbital mg/kg) haloperidol (0.03–0.3 mg/kg), alone or in combination with (5.6–30 were determined mice. second on sucrose intake (4–16 (8–64 (4–32 (0.04–0.4 rats. Results: Cocaine caused a dose-related increase activity mice, whereas 2-1068, decreases. dopamine antagonist haloperidol, at dose that had no effect by itself, but not pentobarbital, attenuated activity. Cocaine, ganaxolone, produced decreases rats; variable. As effects, decrease intake. addition, 2-1068. Pentobarbital statistically significant dose-response function. Conclusions: These results suggest interaction neuroactive steroids extends pharmacologic actions beyond anticonvulsant efficacy, blockade does apply all behaviors.