A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
作者： Lawrence O. Olala , Mutsa Seremwe , Ying-Ying Tsai , Wendy B. Bollag
DOI: 10.1016/J.MCE.2012.11.008
关键词: Aldosterone 、 Biology 、 Adrenocortical carcinoma 、 Internal medicine 、 PROTEIN KINASE D 、 Angiotensin II 、 Zona glomerulosa 、 Cell 、 Endocrinology 、 Mineralocorticoid 、 Phospholipase D
摘要: The mineralocorticoid aldosterone plays an important role in regulating blood pressure, with excess causing hypertension and exacerbating cardiovascular disease. Previous studies have indicated a for both phospholipase D (PLD) protein kinase (PKD) angiotensin II (AngII)-regulated production adrenal glomerulosa cells. Therefore, the relationship between AngII-activated PLD PKD was determined two cell models, primary bovine zona (ZG) HAC15 human adrenocortical carcinoma cells, using inhibitors, 1-butanol reported inhibitor, fluoro-2-indolyl des-chlorohalopemide (FIPI). FIPI first confirmed to decrease activation response AngII models. Subsequently, it shown that inhibited AngII-elicited production. These results indicate is downstream of suggest one mechanisms through which promotes
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