Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.
作者： Lawrence O. Olala , Brian A. Shapiro , Todd C. Merchen , James J. Wynn , Wendy B. Bollag
DOI: 10.1016/J.MCE.2014.05.015
关键词:
摘要: Recent evidence has shown a role for the serine/threonine protein kinase D (PKD) in regulation of acute aldosterone secretion upon angiotensin II (AngII) stimulation. However, mechanism by which AngII activates PKD remains unclear. In this study, using both pharmacological and molecular approaches, we demonstrate that AngII-induced activation is mediated C (PKC) Src family kinases primary bovine adrenal glomerulosa cells leads to increased production. The pan PKC inhibitor Ro 31-8220 inhibitors PP2 Src-1 inhibited Additionally, like dominant-negative serine-738/742-to-alanine mutant cannot be phosphorylated PKC, tyrosine-463-to-phenylalanine mutant, not phosphorylatable Src/Abl pathway, Taken together, our results via involving underlie
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