Glycine receptor heterogeneity in rat spinal cord during postnatal development
作者： C. M. Becker , W. Hoch , H. Betz
DOI: 10.1002/J.1460-2075.1988.TB03255.X
关键词: Glycine receptor 、 Biology 、 Endocrinology 、 Inhibitory postsynaptic potential 、 Protein subunit 、 Glycine 、 Receptor 、 Postsynaptic potential 、 Gene isoform 、 Strychnine 、 Internal medicine 、 Molecular biology
摘要: Two different isoforms of the inhibitory glycine receptor were identified during postnatal development rat spinal cord. A neonatal form characterized by low strychnine binding affinity, altered antigenicity, and a ligand subunit differing in mol. wt (49 kd) from that adult (48 predominates at birth (70% total protein). Separation could be achieved either use selective antibody or gradient elution 2-aminostrychnine affinity columns. Both co-purify with 93 kd peripheral membrane protein postsynaptic complex.
sci-hub.se 参考文章(37)
P. G. Nelson, B. R. Ransom, M. Henkart, P. N. Bullock, Mouse spinal cord in cell culture. IV. Modulation of inhibitory synaptic function Journal of Neurophysiology. ,vol. 40, pp. 1178- 1187 ,(1977) , 10.1152/JN.1977.40.5.1178
ZW Hall, PD Gorin, L Silberstein, C Bennett, A postnatal change in the immunological properties of the acetylcholine receptor at rat muscle endplates The Journal of Neuroscience. ,vol. 5, pp. 730- 734 ,(1985) , 10.1523/JNEUROSCI.05-03-00730.1985
CM Becker, I Hermans-Borgmeyer, B Schmitt, H Betz, The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization The Journal of Neuroscience. ,vol. 6, pp. 1358- 1364 ,(1986) , 10.1523/JNEUROSCI.06-05-01358.1986
M.M. Smith, J. Lindstrom, J.P. Merlie, Formation of the alpha-bungarotoxin binding site and assembly of the nicotinic acetylcholine receptor subunits occur in the endoplasmic reticulum. Journal of Biological Chemistry. ,vol. 262, pp. 4367- 4376 ,(1987) , 10.1016/S0021-9258(18)61357-2
GABRIELE GRENNINGLOH, ECKART GUNDELFINGER, BERTRAM SCHMITT, HEINRICH BETZ, MARK G. DARLISON, ERIC A. BARNARD, PETER R. SCHOFIELD, PETER H. SEEBURG, Glycine vs GABA receptors Nature. ,vol. 330, pp. 25- 26 ,(1987) , 10.1038/330025B0
D. J. Anderson, G. Blobel, Identification of homo-oligomers as potential intermediates in acetylcholine receptor subunit assembly. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 4359- 4363 ,(1983) , 10.1073/PNAS.80.14.4359
David GRAHAM, Fridhelm PFEIFFER, Heinrich BETZ, Photoaffinity-Labelling of the Glycine Receptor of Rat Spinal Cord FEBS Journal. ,vol. 131, pp. 519- 525 ,(1983) , 10.1111/J.1432-1033.1983.TB07292.X
D.R. Curtis, L. H�sli, G.A.R. Johnston, I.H. Johnston, The hyperpolarization of spinal motoneurones by glycine and related amino acids. Experimental Brain Research. ,vol. 5, pp. 235- 258 ,(1968) , 10.1007/BF00238666
J Bormann, O P Hamill, B Sakmann, Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. The Journal of Physiology. ,vol. 385, pp. 243- 286 ,(1987) , 10.1113/JPHYSIOL.1987.SP016493
Richard A. Altschuler, Heinrich Betz, Marianne H. Parakkal, Karen A. Reeks, Robert J. Wenthold, Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor. Brain Research. ,vol. 369, pp. 316- 320 ,(1986) , 10.1016/0006-8993(86)90542-1