Serum Homocysteine in Relation to Mortality and Morbidity From Coronary Heart Disease A 24-Year Follow-Up of the Population Study of Women in Gothenburg
作者： Dimitri Edin Zylberstein , Calle Bengtsson , Cecilia Björkelund , Sverre Landaas , Valter Sundh
DOI: 10.1161/01.CIR.0000112581.96154.EA
关键词: Medicine 、 Internal medicine 、 Myocardial infarction 、 Homocysteine 、 Population 、 Incidence (epidemiology) 、 Surgery 、 Relative risk 、 Cohort 、 Risk factor 、 Population study
摘要: Background— Elevated serum total homocysteine (tHcy) is an established risk factor for cardiovascular disease (CVD), especially in men. However, there are few prospective population studies on female cohorts, and none of these has been longer than 13 years. Methods Results— The Population Study Women Gothenburg began 1968/1969, at which time a representative population-based cohort women aged 38, 46, 50, 54, 60 years was recruited. present follow-up 1368 the original whom blood samples were stored who free previous acute myocardial infarction (AMI) 1968/1969 baseline. Homocysteine analyzed 2001 with frozen from baseline study related to AMI incidence mortality during 24 follow-up. Cox regression analyses used adjustment age, traditional factors, tHcy modifiers. For fifth quintile, relative 1.86 (95% CI 1.06 3.26) 5.14 2....
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