Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application.

摘要: For the development of any colloidal system, thorough characterization is extremely essential. This article discusses physicochemical sildenafil-loaded solid lipid nanoparticle dispersions (SLN) including stability analysis over 6 months time period for possible pulmonary administration treatment arterial hypertension (PAH). SLN consisting phospholipid and triglycerides were manufactured using a novel microchannel homogenization method. These then subjected to namely, particle size distribution shelf life, differential scanning calorimetry (DSC), wide angle X-ray diffraction (WAXD) nebulization performance these by means next generation impactor (NGI). Additionally, morphology nebulized particles was assessed transmission electron microscopy negative staining technique. The solubility sildenafil citrate base in matrix determined 0.1% w/w 1% w/w, respectively. From measurements, it observed that without demonstrated consistent sizes months. SLN, increased found after manufacturing further within weeks. WAXD studies, high intensity reflections corresponding stable β modification observed. DSC results, peak minimum temperatures upon storage, hinting at transformation case SLN. Hence, can be concluded even small drug concentration influences stability.