Active smoking causes oxidative stress and decreases blood melatonin levels.
作者： Fehmi Ozguner , Ahmet Koyu , Gokhan Cesur
DOI: 10.1191/0748233705TH211OA
关键词: Antioxidant 、 Malondialdehyde 、 Endocrinology 、 Oxidative stress 、 Melatonin 、 Superoxide dismutase 、 Glutathione peroxidase 、 Free-radical theory of aging 、 Lipid peroxidation 、 Chemistry 、 Internal medicine
摘要: Oxidative effects via free radical generation in smokers have been widely investigated. They cause lipid peroxidation, oxidation of proteins and damage to mainly lung other tissues. In humans, antioxidative capacity serum is related antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) melatonin. The effect cigarette smoking on plasma levels melatonin has not established together yet. Also, it may be clear if are affected by a protective smoking-induced damage. aim this study investigate the relationship between including melatonin, powerful endogenous antioxidant, teenage girls who active smokers. Additionally, malondialdehyde (MDA) were determined those smoked at least one packet day for three or more years. MDA used as convenient index peroxidation-related oxidative Twenty-one young female School Nursing 21 nonsmoking students (as controls) same school included study. activities two principal SOD, GSH-Px significantly increased but content blood was decreased compared nonsmokers. spite an increase enzyme activities, slightly This indicates that self-defence mechanisms sufficiently protect respiratory system from smoke-mediated injury. result low It seems can reduce induced smoke. Further experimental investigations with exogenous treatments will needed.
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Wenbo Qi, Russel J. Reiter, Dun-Xian Tan, Lucien C. Manchester, Juan R. Calvo, Melatonin prevents δ-aminolevulinic acid-induced oxidative DNA damage in the presence of Fe2+ Molecular and Cellular Biochemistry. ,vol. 218, pp. 87- 92 ,(2001) , 10.1023/A:1007225809674
L. Flohé, F. ötting, Superoxide dismutase assays. Methods in Enzymology. ,vol. 105, pp. 93- 104 ,(1984) , 10.1016/S0076-6879(84)05013-8
Barry Halliwell, John M.C. Gutteridge, Role of free radicals and catalytic metal ions in human disease: an overview. Methods in Enzymology. ,vol. 186, pp. 1- 85 ,(1990) , 10.1016/0076-6879(90)86093-B
A Z Reznick, C E Cross, M L Hu, Y J Suzuki, S Khwaja, A Safadi, P A Motchnik, L Packer, B Halliwell, Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation Biochemical Journal. ,vol. 286, pp. 607- 611 ,(1992) , 10.1042/BJ2860607
JACK L. SMITH, ROBERT E. HODGES, Serum Levels of Vitamin C in Relation to Dietary and Supplemental Intake of Vitamin C in Smokers and Nonsmokers Annals of the New York Academy of Sciences. ,vol. 498, pp. 144- 152 ,(1987) , 10.1111/J.1749-6632.1987.TB23758.X
Eun-Mi Park, Young-Mee Park, Young-Seob Gwak, None, Oxidative Damage in Tissues of Rats Exposed to Cigarette Smoke Free Radical Biology and Medicine. ,vol. 25, pp. 79- 86 ,(1998) , 10.1016/S0891-5849(98)00041-0
Barry Halliwell, John M.C. Gutteridge, Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Letters. ,vol. 307, pp. 108- 112 ,(1992) , 10.1016/0014-5793(92)80911-Y
CHARLES D. SMITH, JOHN M. CARNEY, TOHRU TATSUMO, EARL R. STADTMAN, ROBERT A. FLOYD, WILLIAM R. MARKESBERY, Protein oxidation in aging brain. Annals of the New York Academy of Sciences. ,vol. 663, pp. 110- 119 ,(1992) , 10.1111/J.1749-6632.1992.TB38654.X
JOHN N. DIANA, Tobacco Smoking and Nutrition Annals of the New York Academy of Sciences. ,vol. 686, pp. 1- 11 ,(1993) , 10.1111/J.1749-6632.1993.TB39147.X
Kevin Mccusker, John Hoidal, Selective increase of antioxidant enzyme activity in the alveolar macrophages from cigarette smokers and smoke-exposed hamsters The American review of respiratory disease. ,vol. 141, pp. 678- 682 ,(1990) , 10.1164/AJRCCM/141.3.678