Early Alteration of Kidney Function in Nonuremic Type 1 Diabetic Islet Transplant Recipients Under Tacrolimus-Mycophenolate Therapy

摘要: BACKGROUND Transplant patients on tacrolimus therapy exhibit a reduced glomerular filtration rate (GFR). The type of graft and immune treatment protocol may influence the extent reversibility this side effect. METHODS present single-center study is conducted in 48 nonuremic 1 diabetic recipients an intraportal islet-cell under maintenance immunosuppression (IS) with mycophenolate mofetil. Estimated GFR (eGFR) albuminuria were followed up to 5 years posttransplantation. RESULTS Mean eGFR values decreased by 19 mL/min/1.73 m after 2 weeks IS (P<0.0001) then remained stable throughout complete period. decrease was related predose trough concentrations or doses disappeared upon its discontinuation; it also associated presence at time transplantation. Tacrolimus resulted reduction albuminuria; discontinuation restored initial levels. CONCLUSIONS use our transplant caused 20% eGFR, which reversible following discontinuation, least within 5-year follow-up reversible, compatible tacrolimus-induced preglomerular vasoconstriction. These observations support further regimen patient population.