Contractile effects of tacrolimus in human and rat isolated renal arteries.
作者： E. Schwertfeger , J. Wehrens , V. Oberhauser , A. Katzenwadel , L. C. Rump
DOI: 10.1046/J.1365-2680.2001.00228.X
关键词:
摘要: 1. We tested the vasoactive properties of immunosuppressive drug FK 506 (tacrolimus) in preconstricted rat and human isolated renal arteries vitro. 2. In arteries, tacrolimus (3, 10 microM) showed a direct dose-dependent contractile effect by maximally 23 microm (10% noradrenaline effect), which was only observed presence intact endothelium. Moreover, lower concentration (1 potentiated pressor responses to sympathetic neurotransmitter but not ATP this species. ATP- (0.01-10 induced vasodilation affected microM). 3. contrast, interlobar failed induce vasoconstriction did significantly potentiate constrictor noradrenaline. Acetylcholine-(1 much smaller than suggesting lack functional endothelium preparation. 4. The findings suggest that releases an endothelium-derived constricting factor increase vascular tone is probably because absence or necessary mediator mechanism.
sci-hub.se 参考文章(20)
W. Remmele, Peritoneum, Retroperitoneum, Hernien Pathologie: Ein Lehr- und Nachschlagebuch. pp. 539- 587 ,(1984) , 10.1007/978-3-642-69454-7_9
J.B Copley, C Staffeld, J Lindberg, A Hansen, C Bailey, R Anand, P Van Veldhuisen, Cyclosporine to tacrolimus: effect on hypertension and lipid profiles in renal allografts. The International Congress on Immunosuppression. ,vol. 30, pp. 1254- 1256 ,(1998) , 10.1016/S0041-1345(98)00232-2
Jörg Radermacher, Matthias Behrend, Karl M. Koch, Martina Meiners, Reinhard Brunkhorst, Rudolf Pichlmayr, Cornelia Bramlage, Volker Kliem, Hans J. Schlitt, Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506 Transplant International. ,vol. 11, pp. 3- 10 ,(1998) , 10.1007/S001470050094
J Galle, E Bassenge, R Busse, Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle. Circulation Research. ,vol. 66, pp. 1287- 1293 ,(1990) , 10.1161/01.RES.66.5.1287
J Galle, I Schenck, P Schollmeyer, C Wanner, Cyclosporine and oxidized lipoproteins affect vascular reactivity. Influence of the endothelium. Hypertension. ,vol. 21, pp. 315- 321 ,(1993) , 10.1161/01.HYP.21.3.315
Urs Scherrer, Susanne F. Vissing, Barbara J. Morgan, Julia A. Rollins, Richard S.A. Tindall, Steves Ring, Peter Hanson, Pramod K. Mohanty, Ronald G. Victor, Cyclosporine-Induced Sympathetic Activation and Hypertension after Heart Transplantation New England Journal of Medicine. ,vol. 323, pp. 693- 699 ,(1990) , 10.1056/NEJM199009133231101
John J. Curtis, Hypertension Following Kidney Transplantation American Journal of Kidney Diseases. ,vol. 23, pp. 471- 475 ,(1994) , 10.1016/S0272-6386(12)81015-8
STEPHEN C. TEXTOR, VINCENT J. CANZANELLO, SANDRA J. TALER, DANIEL J. WILSON, LORA L. SCHWARTZ, JO E. AUGUSTINE, JOANN M. RAYMER, J. CARLOS ROMERO, RUSSELL H. WIESNER, RUUD A.F. KROM, JOHN C. BURNETT, Cyclosporine-induced hypertension after transplantation. Mayo Clinic proceedings. ,vol. 69, pp. 1182- 1193 ,(1994) , 10.1016/S0025-6196(12)65772-3
A. David Mayer, Jan Dmitrewski, Jean-Paul Squifflet, Tatjana Besse, Bernd Grabensee, Barbara Klein, Friedrich W. Eigler, Uwe Heemann, Rudolf Pichlmayr, Matthias Behrend, Yves Vanrenterghem, Jan Donck, Johannes van Hooff, Maarten Christiaans, Jose M. Morales, Amado Andres, Robert W.G. Johnson, Colin Short, Bernd Buchholz, Nikola Rehmert, Walter Land, Stefan Schleibner, John L.R. Forsythe, David Talbot, Hans-H. Neumayer, Ingeborg Hauser, Bo-G??ran Ericzon, Christina Brattstr??m, Kerstin Claesson, Ferdinand M??hlbacher, Erich Pohanka, Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection - A report of the European Tacrolimus Multicenter Renal Study Group Transplantation. ,vol. 64, pp. 436- 443 ,(1997) , 10.1097/00007890-199708150-00012
Jean-Vivien Mombouli, Paul M. Vanhoutte, Endothelial dysfunction: from physiology to therapy. Journal of Molecular and Cellular Cardiology. ,vol. 31, pp. 61- 74 ,(1999) , 10.1006/JMCC.1998.0844