Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506

摘要: This prospective study investigated hypertension and renal vasoconstriction developing during the 1st year after transplantation in patients randomly allocated to treatment with FK 506 (n = 28) or CyA 13). Starting doses were 0.2–0.3 mg/kg per day for 5–8 CyA; subsequently adjusted trough levels (5–15 ng/ml 100–150 CyA). We compared 24-h ambulatory blood pressure measurement, antihypertensive treatment, serum creatinine, resistance index (RI), measured by Doppler ultrasound at level of interlobar artery. Until month 2 506-treated had a significantly lower RI (8 %) better graft function, as evidenced creatinine values. Some 13 % patients, 70 CyA-treated (P < 0.01), needed additional drugs keep stable. above-mentioned dosages, was associated higher number infections (urinary tract infection, pyelonephritis, pneumonia). conclude that produces greater systemic than 506, reflected artery values need treatment. After months reduction levels, effects (i. e., values), but not hypertensive effects, disappear.