Cyclosporine-Induced Sympathetic Activation and Hypertension after Heart Transplantation

摘要: Abstract Background. Hypertension is a frequent complication of cyclosporine-induced immunosuppression, but the underlying mechanism unknown. In anesthetized animals, administration cyclosporine increases sympathetic-nerve discharge, which may contribute to hypertension. Methods. To determine whether hypertension accompanied by sustained sympathetic neural activation in patients, we recorded action potentials using intraneural microelectrodes (in peroneal nerve) heart-transplant recipients receiving azathioprine and prednisone alone (n = 5) or combination with 14). We performed same studies eight patients myasthenia gravis who were not, five essential hypertension, nine normal controls. Results. Heart-transplant cyclo-sporine had higher mean arterial blood pressure (±SE) than those not (112±3 vs. 96±4 mm Hg; P<0....