Cyclosporine-induced hypertension after transplantation.

摘要: Objective To describe the features and mechanisms of posttransplantation hypertension suggest appropriate management disorder. Design We review our own experience reports from literature on in cyclosporine A (CSA)-treated transplant recipients. Results Soon after immunosuppression with CSA corticosteroids, develops most patients who undergo transplantation. The blood pressure increases, which are usually moderate, occur universally because increased peripheral vascular resistance. Disturbances circadian patterns lead to loss normal nocturnal decline, a feature that magnifies hypertensive target effects. Changes sometimes severe associated rapidly developing injury, including intracranial hemorrhage, left ventricular hypertrophy, microangiopathic hemolysis. complex underlie this disorder include alterations reactivity cause widespread vasoconstriction. Vascular effects kidney reduced glomerular filtration impaired sodium excretion. Many these changes affect local regulation tone, stimulation endothelin suppression vasodilating prostaglandins. Effective therapy includes use agents, often calcium channel blocking drugs. Caution must be exercised avoid interfering disposition or aggravating adverse relative electrolyte homeostasis. Conclusion Recognition treatment CSA-induced injury important elements managing recipient.