Chrysin and luteolin alleviate vascular complications associated with insulin resistance mainly through PPAR-γ activation.

摘要: Chrysin and luteolin are two flavonoids with Peroxisome proliferators-activated receptor γ (PPAR-γ) stimulating activity. Here, we investigated the protective effect of chrysin from vascular complications associated insulin resistance (IR). IR was induced in rats by drinking fructose for 12 weeks while were given 6 or without PPAR-γ antagonist, bisphenol A diglycidyl ether (BADGE). Then, blood pressure (BP) recorded serum levels glucose, insulin, advanced glycation end products (AGEs) lipids measured. Concentration response curves phenylephrine (PE), KCl, acetylcholine (ACh) obtained thoracic aorta rings. Aortic reactive oxygen species (ROS) nitric oxide (NO) generation also studied. significantly alleviated systolic BP elevations caused IR, co-administration BADGE prevented alleviation. Although, neither nor affected ACh impaired vasodilatation, they both exaggerated vasoconstrictions to PE KCl animals. In addition, incubation animals KCl. On other hand, co-incubation GW9662, selective Both inhibited developed hyperinsulinemia increases AGEs, while, reduced on dyslipidemia. markedly elevated NO ROS aortae did not change their ROS. conclusion, alleviate mainly through dependent pathways.