Cinnamaldehyde protects from the hypertension associated with diabetes.
作者： Hany M. El-Bassossy , Ahmed Fahmy , Dina Badawy
DOI: 10.1016/J.FCT.2011.07.060
关键词:
摘要: Abstract Here we investigated cinnamaldehyde (CA) effect on diabetes-induced hypertension. Insulin deficiency was induced by streptozotocin while, insulin resistance fructose. Rats were left 8 weeks or 12 weeks after STZ fructose administration respectively. CA (20 mg kg −1 day ) daily administered in the last 6 weeks. Then, blood pressure (BP) recorded. Isolated Aorta reactivity to phenylephrine (PE), KCl, acetylcholine (ACh) studied as well nitric oxide (NO) generation plus Ca 2+ influx. associated with elevated BP, increased response PE and decreased ACh impaired NO generation. treatment prevented hyperglycemia its vascular reactivity. BP this elevation. ACh, while normalized KCl but not ACh. accompanied reduced exaggerated influx restored normal did affect In conclusion, prevents development of hypertension through normalization contractility addition insulinotropic deficiency.
elsevier.com
sci-hub.se 参考文章(32)
Wei ZHANG, Yan-cheng XU, Fang-jian GUO, Ye MENG, Ming-li LI, Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Chinese Medical Journal. ,vol. 121, pp. 2124- 2128 ,(2008) , 10.1097/00029330-200811010-00003
Hany M. El-Bassossy, Nabila N. El-Maraghy, Hassan M. El-Fayoumi, Malcolm L. Watson, Haem oxygenase-1 induction protects against tumour necrosis factor α impairment of endothelial-dependent relaxation in rat isolated pulmonary artery British Journal of Pharmacology. ,vol. 158, pp. 1527- 1535 ,(2009) , 10.1111/J.1476-5381.2009.00419.X
Prachi Anand, K.Y. Murali, Vibha Tandon, P.S. Murthy, Ramesh Chandra, Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats Chemico-Biological Interactions. ,vol. 186, pp. 72- 81 ,(2010) , 10.1016/J.CBI.2010.03.044
Soter Dai, John H. McNeill, Fructose-induced hypertension in rats is concentration- and duration-dependent. Journal of Pharmacological and Toxicological Methods. ,vol. 33, pp. 101- 107 ,(1995) , 10.1016/1056-8719(94)00063-A
Hany M. El-Bassossy, Mohamed A. El-Moselhy, Mona F. Mahmoud, Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 384, pp. 277- 285 ,(2011) , 10.1007/S00210-011-0669-Z
Shridhar N. Iyer, Michael J. Katovich, Vascular Reactivity to Phenylephrine and Angiotensin II in Hypertensive Rats Associated with Insulin Resistance Clinical and Experimental Hypertension. ,vol. 18, pp. 227- 242 ,(1996) , 10.3109/10641969609081766
Fabiano E Xavier, Ana Paula C Davel, Luciana V Rossoni, Dalton V Vassallo, Time-dependent hyperreactivity to phenylephrine in aorta from untreated diabetic rats: role of prostanoids and calcium mobilization. Vascular Pharmacology. ,vol. 40, pp. 67- 76 ,(2003) , 10.1016/S1537-1891(02)00315-4
Ka Bian, Hai-xia Shi, Ferid, Yong-liang Xue, Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta Vascular Health and Risk Management. ,vol. 7, pp. 273- 280 ,(2011) , 10.2147/VHRM.S15429
Feng Sui, Na Lin, Jian-You Guo, Chang-Bin Zhang, Xin-Liang Du, Bao-Sheng Zhao, Hong-Bin Liu, Na Yang, Lan-Fang Li, Shu-Ying Guo, Hai-Ru Huo, Ting-Liang Jiang, Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro. Journal of Asian Natural Products Research. ,vol. 12, pp. 76- 87 ,(2010) , 10.1080/10286020903451732
Shang-Tzen Chang, Pin-Fun Chen, Shan-Chwen Chang, Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. Journal of Ethnopharmacology. ,vol. 77, pp. 123- 127 ,(2001) , 10.1016/S0378-8741(01)00273-2