SCHIZOPHRENIA AND THE LIMBIC SYSTEM

作者: E. Fuller Torrey , MichaelR. Peterson

DOI: 10.1016/S0140-6736(74)91143-X

关键词: ProprioceptionPathologicalNeuropathologyLimbic systemPsychiatryDiseaseNeuroscienceEncephalitisEpilepsySchizophrenia

摘要: Abstract There is accumulating evidence that Summary the brain's limbic system pathologically involved in at least some cases of schizophrenia. The comes from schizophrenia-like symptoms observed known limbic-system neuropathology, and signs dysfunction patients diagnosed with Prominent first group are temporallobe epilepsy, encephalitis, brain tumours. Suggestions found studies earliest changes by schizophrenic themselves, site action psychedelic drugs, electro-encephalographic abnormalities schizophrenics. Whereas results scalp-electrode schizophrenics remain equivocal, four separate using implanted electrodes have recorded electrical specifically structures. Recent findings " soft neurological patients, including autonomic dysfunction, proprioception, vestibular eye-tracking, also point towards disturbances subcortical area which includes system. Although pathological been described schizophrenia, failure to follow up and/or replicate such leaves these doubt. linking although admittedly circumstantial, sufficient warrant a serious look for further clues. appears be part choice elucidating biology pathomorphology this disease.

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