IS CYCLIC AMP THE MEDIATOR OF CYTOPROTECTION BY PROSTAGLANDINS IN HUMAN GASTRIC MUCOSA

摘要: SUMMARY Several prostaglandins protect the gastrointestinal mucosa against a variety of agents which have potential ability to cause cell damage and necrosis - an effect has been called “ cytoprotection Cytoprotection is independent antisecretory prostaglandins, but cellular mechanisms underlie prostaglandin-induced not identified. An increase in intracellular cyclic AMP suggested play crucial role latter action. A with potent cytoprotective properties were tested for their capacity modulate adenylate cyclase activity homogenates human gastric corpus antral mucosa. PG E 2 prostacyclin (PG I 2) able stimulate dose-dependently system mucosal biopsies. Cytoprotective without such as F s 15(S)-methyl- also activate enzyme dose-related manner both well region stomach. By contrast, prostaglandin D 2, analogues 1 SC-29333, S 76 8706 8708 prostaglandin-like compound C 83 did As opposed was ineffective modulating at all, SC-29333 inhibited basal 2- sensitive activities concentrations beyond 1×10 −5 mol/l. These studies suggest that directly related action