Effects of E prostaglandins on canine gastric potential difference
作者： Esam Z. Dajani , David A. Callison , Ralph E. Bertermann
DOI: 10.1007/BF01072927
关键词:
摘要: Measurement of the gastric transmucosal potential difference (PD) was used to study effect antisecretory prostaglandins on integrity mucosa Heidenhain pouch dog. Intragastric administration SC-29333 [(+/-)-15-deoxy-16-alpha,beta-hydroxy-16-methyl PGE1 methyl ester] slightly but significantly increased PD when compared vehicle control. In addition, administered either intravenously or intragastrically, inhibited fall induced by aspirin, a well-established barrier breaker. contrast, intragastric 16,16-dimethyl PGE2 ester (Me-PGE2) lowered and failed modify actions aspirin mucosa. However, intravenous prostaglandin did not affect basal values. These studies suggest that may strengthen mucosal against this could have important therapeutic potential.
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