Hantavirus Pulmonary Syndrome: The First 100 US Cases

摘要: In the spring of 1993, hantavirus pulmonary syndrome (HPS) "emerged" in southwestern United States, where a multiagency investigation led to rapid description this new clinical entity and its etiology. Analysis first 100 US cases identified showed that disease was distributed 21 states, had gone unrecognized since at least 1959, distinct spring-early summer seasonality. Of infected persons, 54% were male; 63% Caucasian, 35% Native American, 2% African American. The average age case-patients 34.9 years, 8 children or adolescents aged < = 16 years. overall case-fatality rate 52%. There 91% concordance among serologic, immunohistochemical, molecular results. HPS States is caused by three newly described pathogenic hantaviruses, each which has rodent host, have been recently recognized Canada South America. National surveillance sporadic remains essential for further defining epidemiology spectrum.