Hippocampal neurogenesis in adult Old World primates.

摘要: The production of new hippocampal neurons in adulthood has been well documented rodents. Recent studies have extended these findings to other mammalian species, such as tree shrews and marmoset monkeys. However, neurogenesis not demonstrated adult Old World primates. To investigate this possibility, we injected 11 monkeys different ages (5–23 years) with the thymidine analog bromodeoxyuridine examined fate labeled cells at survival times by using neuronal glial markers. In young-adult middle-aged monkeys, found a substantial number that incorporated exhibited morphological biochemical characteristics immature mature neurons. New located dentate gyrus expressed marker granule neurons, Turned On After Division 64 kDa protein, markers including neuron specific enolase, nuclei, calcium-binding protein calbindin. Fewer astroglial fibrillary acidic protein. Evidence was observed oldest (23 well, but it appeared be less robust. These results indicate brains produce Adult macaque may provide useful primate model for studying functional significance neurogenesis.