Pike. A nuclear GTPase that enhances PI3kinase activity and is regulated by protein 4.1N
作者： Keqiang Ye , K.Joseph Hurt , Frederick Y Wu , Ming Fang , Hongbo R Luo
DOI: 10.1016/S0092-8674(00)00195-1
关键词: Cyclin D1 、 Cytoplasm 、 Lipid kinase activity 、 Biology 、 Pike 、 Cell biology 、 GTPase 、 Downregulation and upregulation 、 Plasma protein binding 、 Biochemistry 、 GTPase-activating protein
摘要: While cytoplasmic PI3Kinase (PI3K) is well characterized, regulation of nuclear PI3K has been obscure. A novel protein, PIKE (PI3Kinase Enhancer), interacts with to stimulate its lipid kinase activity. encodes a 753 amino acid GTPase. Dominant-negative prevents the NGF enhancement and upregulation cyclin D1. treatment also leads interactions 4.1N, which translocated nucleus, fitting initial identification based on binding 4.1N in yeast two-hybrid screen. Overexpression abolishes effects PI3K. Activation by inhibited NGF-stimulated translocation nucleus. Thus, physiologically modulates activation
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