Brain–blood ratio: implications in brain drug delivery

摘要: Introduction: The brain–blood ratio is an important model correlating the brain-targeting ability of neurotherapeutics with CNS pharmacokinetics, which need to be presented before scientific community for exploration its worth. purpose this article bring key concept and precise discussion attention researchers.Areas covered: Three major points are discussed herein: First, significance respect investigational neurotherapeutics, carrier systems correlation research findings brain targeting efficiency. Second, various factors influencing ratio. Third, strategies enhancing In addition, benchmark criteria CNS-likeness drug molecules have been tabulated.Expert opinion: (also referred as brain–plasma ratio) repre...