Efficacy of olanzapine and ziprasidone for the treatment of schizophrenia: a systematic review.

摘要: It is difficult to determine the relative efficacy of atypical antipsychotics for treatment schizophrenia, based on available literature. The purpose this article review and compare two antipsychotics: olanzapine ziprasidone. This focused randomised trials in which these were compared with placebo, conventional each other. Common measures Brief Psychiatric Rating Scale, Positive Negative Syndrome Scale Schedule Assessment Symptoms. When sufficient data available, mean effect (with 95% confidence intervals) was computed presented. Olanzapine consistently found be significantly superior placebo comparable with, or to, haloperidol overall, positive negative schizophrenic symptoms. Ziprasidone appears have greater than overall symptoms, but it remains uncertain whether ziprasidone such as haloperidol. Two unpublished clinical directly One no significant differences between drugs, whereas results other study favoured olanzapine. Compared ziprasidone, has a larger body evidence supporting its efficacy, proportion findings been published, allowing scrutiny results. Both drugs appear symptoms generally compares more favourably antipsychotics. Firm conclusions regarding comparison require additional published particularly direct