Substance P-like immunoreactive neurons are depleted in Alzheimer's disease cerebral cortex.

摘要: Abstract We studied the morphology and distribution of substance P-like immunoreactive elements in normal Alzheimer's disease brain with a monoclonal anti-substance P antibody. Bands prominent terminal-like staining were found dentate gyrus brain. Multipolar P-immunoreactive neurons seen polymorphic layer CA4 fiber was present CA fields hippocampus adjacent allocortex. Reactive perikarya, concentrated deep cortex infracortical white matter, all isocortical regions. Greatest density frontal parietal association cortex; lowest visual cortex. Fiber generally greatest layers I II. In disease, intensity reduced gyrus. Hilar unaffected but other field distorted pruned dendritic trees. Isocortical perikarya fibers significantly depleted Globular deposits consisting neuntes or dissolving frequently seen. Double methods showed that vast majority isocortical, not hippocampal, are nicotinamide adenine dinucleotide phosphate diaphorase-positive. Despite modest quantitative depletion as measured by radioimmunoassay compared to somatostatin, there is significant perikarya. This disparity may be due persistence afferent projections which make major contribution concentrations cerebral high content dystrophic