Abnormalities in Non-Cholinergic Neurotransmitter Systems in Alzheimer’s Disease

摘要: The identification of an abnormality in cholinergic transmission Alzheimer’s disease (AD) was a pivotal observation the history research into disease. It prompted reappraisal mechanistic basis for symptoms AD; it stimulated significance other neurotransmitter systems and provided clear pharmacological target therapeutic drug development. However, view that all AD are predominantly (or exclusively) reflection deficit is now difficult to sustain. enormity overt structural alterations evident throughout CNS patients dying with does not equate minor contribution (numerically) acetylcholine synaptic compared major excitatory inhibitory amino acid neurotransmitters. that, at least postmortem, there abnormalities wide variety systems. This consistent studies pathology which indicate few brain regions do exhibit some degree neuropathological change. Moreover, widespread nature dysfunction accords spectra cognitive behavioural changes observed during course