摘要: A large number of neuropeptides have been found in cortical neurons. They are therefore interest attempting to demonstrate selective vulnerability different populations neurons Alzheimer's disease (AD). The most consistent neuropeptide deficit AD is reductions concentrations somatostatin. Lesser corticotropin-releasing factor, Y and substance P reported. Concentrations both vasoactive intestinal polypeptide cholecystokinin relatively preserve. morphologic correlate reduced somatostatin appears be markedly distorted terminal fiber plexuses, rather than numbers neuronal perikarya. localized senile plaques.
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