ATP Binding and Hydrolysis-Driven Rate-Determining Events in the RFC-Catalyzed PCNA Clamp Loading Reaction

作者: Miho Sakato , Yayan Zhou , Manju M. Hingorani

DOI: 10.1016/J.JMB.2011.12.018

关键词: BiophysicsProliferating cell nuclear antigenBinding siteProtein structureAdenosine triphosphateDNA replicationBiochemistryBiologyATP hydrolysisDNAReplication factor C

摘要: The multi-subunit replication factor C (RFC) complex loads circular proliferating cell nuclear antigen (PCNA) clamps onto DNA where they serve as mobile tethers for polymerases and …

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