Direct metabolic regulation of β-catenin activity by the p85α regulatory subunit of phosphoinositide 3-OH kinase
作者： Jesús Espada , Héctor Peinado , Manel Esteller , Amparo Cano
DOI: 10.1016/J.YEXCR.2005.01.009
关键词: c-Raf 、 Biology 、 MAP2K7 、 ASK1 、 MAP kinase kinase kinase 、 Cyclin-dependent kinase 9 、 Cell biology 、 Cyclin-dependent kinase complex 、 Biochemistry 、 Serine/threonine-specific protein kinase 、 Casein kinase 2
摘要: Abstract Class IA phosphoinositide 3-OH kinases (PI3K) are lipid composed of catalytic and regulatory subunits. These can regulate the metabolic stability signaling activity β-catenin, a central component E-cadherin/catenin cell–cell adhesion complex, Wnt pathway. This regulation occurs at level glycogen synthase kinase 3 (GSK3), serine/threonine that marks β-catenin to enter destruction In addition, subunit p85α directly binds but role this interaction in context is unknown. Here we report expression exogenous mouse keratinocytes increases has strong synergistic effect on transcriptional β-catenin. Both effects associated formation β-catenin/p85α inhibition β-catenin/APC complexes independent GSK3 PI3K activities. findings suggest act as direct regulator activity.
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