Effect of chronic alcohol vapor exposure on reinstatement of alcohol seeking induced by U50,488.
作者： Douglas Funk , Kathleen Coen , Sahar Tamadon , AD Lê , None
DOI: 10.1016/J.NEUROPHARM.2019.01.017
关键词: Stria terminalis 、 κ-opioid receptor 、 Premovement neuronal activity 、 Alcohol 、 Endocrinology 、 Internal medicine 、 Agonist 、 p38 mitogen-activated protein kinases 、 Alcohol dependence 、 Medicine 、 Stimulation
摘要: Abstract Alcohol dependence and stress are associated with relapse to alcohol during abstinence, but the underlying mechanisms poorly understood. Kappa opioid receptors (KOR) involved in reward effects of stress. Previously, non-dependent rats, we showed that KOR bed nucleus stria terminalis (BNST) mediate reinstatement seeking induced by selective agonist U50,488. Here, determine chronic, intermittent exposure vapor on U50,488-induced seeking. We also study brain using neuronal activity marker Fos phosphorylated p38 MAPK (p-p38), an intracellular messenger implicated stimulation. trained male Long-Evans rats self-administer (12% w/v) exposed them (14 h vapor/10 h air) daily for 24 d or control condition, extinguished alcohol-reinforced responding determined dose response reinstatement. then p-p38 expression. Vapor-exposed were more sensitive U50,488 increased expression areas stress-induced relapse, activation ventral BNST was greater rats. Vapor had basal dorsal BNST, LC NTS. Our findings suggest changes responses stimulation may be sensitivity accompanying dependence.
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