Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects.
作者： A T Birmingham , J L Greaves , C G Wilson
DOI:
关键词: Gamma scintigraphy 、 Medicine 、 Ophthalmic Ointment 、 Surgery 、 Dosage form 、 Healthy subjects 、 Pharmacokinetics 、 Diethylenetriaminepentaacetic acid 、 Ocular surface 、 Volunteer 、 Nuclear medicine
摘要: Abstract 1. The precorneal residence of an ophthalmic ointment radiolabelled by inclusion technetium-99m tin colloid was assessed in seven volunteer subjects using the technique gamma scintigraphy and compared with a solution 0.3% w/v hydroxypropylmethylcellulose, (HPMC) diethylenetriaminepentaacetic acid same subjects. 2. mean half-times (+/- s.d.) corneal were 6490 +/- 5404 s (108 min) for 13 24 HPMC (P < 0.01). 3. area-under-curve value (AUC(0,540 s)), which reflects total time preparation on ocular surface, calculated each vehicle subject. AUC(0,540 s) 42170 5032)% it 8394 4641)%
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