Biochemical basis for deficient paracetamol glucuronidation in cats: an interspecies comparison of enzyme constraint in liver microsomes.
作者： MICHAEL H. COURT , DAVID J. GREENBLATT
DOI: 10.1111/J.2042-7158.1997.TB06822.X
关键词: Biochemistry 、 Enzyme 、 Drug metabolism 、 Toxicity 、 Uridine kinase 、 Microsome 、 Uridine 、 CATS 、 Glucuronidation 、 Biology
摘要: … glucuronidation as a pathway for the conjugation and elimination of paracetamol (Savides et a1 1984). Although the in-vitro metabolism of paracetamol in the cat … in cats compared with …
sci-hub.se 参考文章(15)
John B. Watkins, Curtis D. Klaassen, Xenobiotic Biotransformation in Livestock: Comparison to Other Species Commonly Used in Toxicity Testing1 Journal of Animal Science. ,vol. 63, pp. 933- 942 ,(1986) , 10.2527/JAS1986.633933X
D A Vessey, E S Kempner, In situ structural analysis of microsomal UDP-glucuronyltransferases by radiation inactivation Journal of Biological Chemistry. ,vol. 264, pp. 6334- 6338 ,(1989) , 10.1016/S0021-9258(18)83352-X
P.L.M. Jansen, P.Th. Henderson, Influence of phenobarbital treatment on p-nitrophenol and bilirubin glucuronidation in Wistar rat, Gunn rat and cat. Biochemical Pharmacology. ,vol. 21, pp. 2457- 2462 ,(1972) , 10.1016/0006-2952(72)90416-9
Lisa L. Von Moltke, Melanie Manis, Jerold S. Harmatz, Roger Poorman, David J. Greenblatt, Inhibition of acetaminophen and lorazepam glucuronidationin vitro by probenecid Biopharmaceutics & Drug Disposition. ,vol. 14, pp. 119- 130 ,(1993) , 10.1002/BDD.2510140204
J.O. Miners, K.J. Lillywhite, K. Yoovathaworn, M. Pongmarutai, D.J. Birkett, Characterization of paracetamol UDP-glucuronosyltransferase activity in human liver microsomes Biochemical Pharmacology. ,vol. 40, pp. 595- 600 ,(1990) , 10.1016/0006-2952(90)90561-X
M.Helen morrison, Gabrielle M. Hawksworth, Glucuronic acid conjugation by hepatic microsomal fractions isolated from streptozotocin-induced diabetic rats Biochemical Pharmacology. ,vol. 33, pp. 3833- 3838 ,(1984) , 10.1016/0006-2952(84)90048-0
Celina E. Castuma, Rodolfo R. Brenner, Effect of dietary cholesterol on microsomal membrane composition, dynamics and kinetic properties of UDPglucuronyl transferase. Biochimica et Biophysica Acta. ,vol. 855, pp. 231- 242 ,(1986) , 10.1016/0005-2736(86)90169-0
Zoltan Gregus, John B. Watkins, Thomas N. Thompson, Michael J. Harvey, Karl Rozman, Curtis D. Klaassen, Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing Toxicology and Applied Pharmacology. ,vol. 67, pp. 430- 441 ,(1983) , 10.1016/0041-008X(83)90327-7
Patricio Vega, Carlos Gaule, Emilio Sanchez, Eugenia del Villar, Inhibition and activation of UDP-glucuronyltransferase in alloxanic-diabetic rats. General Pharmacology-the Vascular System. ,vol. 17, pp. 641- 645 ,(1986) , 10.1016/0306-3623(86)90293-4
Karl Walter Bock, Adelheid Forster, Harald Gschaidmeier, Marianne Brück, Peter Münzel, Wolfgang Schareck, Sylvie Fournel-Gigleux, Brian Burchell, Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Biochemical Pharmacology. ,vol. 45, pp. 1809- 1814 ,(1993) , 10.1016/0006-2952(93)90437-2