CORTISOL IN SEVERELY BURNED PATIENTS

摘要: Thermal injuries of more than 20% body surface area lead to conditions resembling a severe systemic inflammatory response syndrome, such as in septic shock. It has been shown that shock may disturbances cortisol metabolism and balance the hypothalamic-pituitary-adrenal axis. To investigate whether disturbance also occurs very early stages syndrome burned patients, we performed 20 corticotropin-releasing hormone tests on day 1 after admission our unit. In 7 secretion could be demonstrated. Four patients developed adrenal insufficiency. The correlation between abbreviated burn severity index risk developing insufficiency was significant (P = 0.008). We observed higher mortality rate adrenally insufficient patients; however, because small patient number, were not able prove this observation with statistical 0.11). Our findings indicate temporary injury. Further investigations will have clarify benefit from replacement.