The effect of sympathetic activity on thermal hyperalgesia in capsaicin-treated skin during body cooling and warming.
关键词: Iontophoresis 、 Capsaicin 、 Inflammation 、 Nociception 、 Internal medicine 、 Adrenergic receptor 、 Phenoxybenzamine 、 Adrenergic antagonist 、 Endocrinology 、 Chemistry 、 Adrenergic
摘要: An adrenergic mechanism is thought to contribute pain in conditions that sometimes develop during chronic inflammation and after nerve or tissue injury. There some doubt, however, about whether activity influences nociception acute inflammation. To investigate this issue, the noncompetitive alpha-(α) antagonist phenoxybenzamine was introduced by iontophoresis into skin of 16 healthy volunteers either before topical application capsaicin. When applied capsaicin, increased thermal hyperalgesia at normal ambient temperatures body warming. These findings suggest blocked an analgesic when onset However, effect disappeared cooling. inhibited temperatures, warming Thus, a hyperalgesic It concluded presence nociceptive α-adrenergic blockage, possibly increasing access excitatory receptors on afferents. influence may overcome inhibitory
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Olsson Y, Microenvironment of the peripheral nervous system under normal and pathological conditions. Critical Reviews in Neurobiology. ,vol. 5, pp. 265- 311 ,(1990)
Detlef Kindgen-Milles, Holger Holthusen, Nociception from blood vessels is independent of the sympathetic nervous system under physiological conditions in humans European Journal of Pharmacology. ,vol. 328, pp. 41- 44 ,(1997) , 10.1016/S0014-2999(97)83025-7
Geoffrey Burnstock, John N Wood, Purinergic receptors: their role in nociception and primary afferent neurotransmission. Current Opinion in Neurobiology. ,vol. 6, pp. 526- 532 ,(1996) , 10.1016/S0959-4388(96)80060-2
Hermann Fuder, Michael Selbach, Characterization of sensory neurotransmission and its inhibition via α2B-adrenoceptors and via non-α2-receptors in rabbit iris Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 347, pp. 394- 401 ,(1993) , 10.1007/BF00165389
Erik Kinnman, Eva-Britt Nygårds, Per Hansson, Peripheral α-adrenoreceptors are involved in the development of capsaicin induced ongoing and stimulus evoked pain in humans Pain. ,vol. 69, pp. 79- 85 ,(1997) , 10.1016/S0304-3959(96)03257-5
R. Baron, G. Wasner, R. Borgstedt, E. Hastedt, H. Schulte, A. Binder, F. Kopper, M. Rowbotham, J. D. Levine, H. L. Fields, Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation Neurology. ,vol. 52, pp. 923- 923 ,(1999) , 10.1212/WNL.52.5.923
Peter D. Drummond, Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin Pain. ,vol. 60, pp. 311- 315 ,(1995) , 10.1016/0304-3959(94)00130-7
Ralph Gonzales, Caroline D. Sherbourne, Marc E. Goldyne, Jon D. Levine, NORADRENALINE-INDUCED PROSTAGLANDIN PRODUCTION BY SYMPATHETIC POSTGANGLIONIC NEURONS IS MEDIATED BY ALPHA 2-ADRENERGIC RECEPTORS Journal of Neurochemistry. ,vol. 57, pp. 1145- 1150 ,(1991) , 10.1111/J.1471-4159.1991.TB08272.X
Régis Matran, Claes-Roland Martling, Jan M. Lundberg, Inhibition of cholinergic and non-adrenergic, non-cholinergic bronchoconstriction in the guinea pig mediated by neuropeptide Y and α2-adrenoceptors and opiate receptors European Journal of Pharmacology. ,vol. 163, pp. 15- 23 ,(1989) , 10.1016/0014-2999(89)90390-7
Jun Sato, Shigeyuki Suzuki, Ryoko Tamura, Takao Kumazawa, Norepinephrine excitation of cutaneous nociceptors in adjuvant-induced inflamed rats does not depend on sympathetic neurons Neuroscience Letters. ,vol. 177, pp. 135- 138 ,(1994) , 10.1016/0304-3940(94)90063-9