Repeated Assessment of Exploration and Novelty Seeking in the Human Behavioral Pattern Monitor in Bipolar Disorder Patients and Healthy Individuals

摘要: BACKGROUND: Exploration and novelty seeking are cross-species adaptive behaviors that dysregulated in bipolar disorder (BD) critical features of the illness. While these have been extensively quantified animals, multivariate human paradigms exploration lacking. The Behavioral Pattern Monitor (hBPM), a version animal open field, identified signature pattern hyper-exploration manic BD patients, but whether exploratory behavior changes with treatment is unknown. objective this study was to assess sensitivity hBPM symptoms, necessary step towards elucidating neurobiology underlying BD. METHODOLOGY AND PRINCIPAL FINDINGS: Twelve acutely hospitalized subjects 21 healthy volunteers were tested over three sessions; all retested one week after their first session two weeks second session. Motor activity, spatial entropic (degree unpredictability) patterns exploration, interactions novel objects quantified. Manic patients demonstrated greater motor extensive more unpredictable object than during sessions. novelty-seeking slightly decreased sessions as symptoms responded treatment, never level volunteers. Among volunteers, did not significantly decrease time, measures highly correlated between CONCLUSIONS/SIGNIFICANCE: showed modest reduction yet still hBPM, suggesting illness may be enduring characteristics Furthermore, subject marked habituation effects. can reliably used repeated-measures design characterize and, parallel studies, contribute developing treatments target neuropsychiatric disease. Language: en